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SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

The sirtuin SIRT4 has been implicated in the control of autophagy and mitochondrial quality control via mitophagy. However, the role of SIRT4 in regulating autophagy/mitophagy induced by different stressors is unclear. Here, we show that cells expressing SIRT4(H161Y), a catalytically inactive, domin...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley 2026-05-01
Schriftenreihe:FEBS Open Bio
Schlagworte:
autophagy
HDAC6
LC3
OPA1
SIRT4
ULK1
Online-Zugang:https://doi.org/10.1002/2211-5463.70164
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