Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model

ABSTRACT Treatment with antibiotics is a major risk factor for Clostridioides difficile infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought to limit C. difficile colonization include the conversion of conjugated primary bile salts into se...

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Detalhes bibliográficos

Principais autores:	Xiaoyun Huang, April E. Johnson, Joshua N. Brehm, Thi Van Thanh Do, Thomas A. Auchtung, Hugh C. McCullough, Armando I. Lerma, Sigmund J. Haidacher, Kathleen M. Hoch, Thomas D. Horvath, Joseph A. Sorg, Anthony M. Haag, Jennifer M. Auchtung
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-02-01
coleção:	mSphere
Assuntos:	Stickland fermentation bile metabolism microbiota antibiotic disruption
Acesso em linha:	https://journals.asm.org/doi/10.1128/msphere.01049-24
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