Doublecortin restricts neuronal branching by regulating tubulin polyglutamylation
Abstract Doublecortin is a neuronal microtubule-associated protein that regulates microtubule structure in neurons. Mutations in Doublecortin cause lissencephaly and subcortical band heterotopia by impairing neuronal migration. We use CRISPR/Cas9 to knock-out the Doublecortin gene in induced pluripo...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Portfolio
2025-02-01
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| Серии: | Nature Communications |
| Online-ссылка: | https://doi.org/10.1038/s41467-025-56951-2 |
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