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Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.

The retinal pigment epithelium (RPE) is a pigmented monolayer of cells lying between the photoreceptors and a layer of fenestrated capillaries, the choriocapillaris. Choroideremia (CHM) is an X-linked progressive degeneration of these three layers caused by the loss of function of Rab Escort protein...

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Principais autores: Silène T Wavre-Shapton, Tanya Tolmachova, Mafalda Lopes da Silva, Clare E Futter, Miguel C Seabra
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2013-01-01
סדרה:PLoS ONE
גישה מקוונת:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057769&type=printable
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