Plasmacytoid dendritic cells orchestrate innate and adaptive anti-tumor immunity induced by oncolytic coxsackievirus A21

Abstract Background The oncolytic virus, coxsackievirus A21 (CVA21), has shown promise as a single agent in several clinical trials and is now being tested in combination with immune checkpoint blockade. Combination therapies offer the best chance of disease control; however, the design of successfu...

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Hlavní autoři:	Louise M. E. Müller, Matthew Holmes, Joanne L. Michael, Gina B. Scott, Emma J. West, Karen J. Scott, Christopher Parrish, Kathryn Hall, Sina Stäble, Victoria A. Jennings, Matthew Cullen, Stewart McConnell, Catherine Langton, Emma L. Tidswell, Darren Shafren, Adel Samson, Kevin J. Harrington, Hardev Pandha, Christy Ralph, Richard J. Kelly, Gordon Cook, Alan A. Melcher, Fiona Errington-Mais
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMJ Publishing Group 2019-07-01
Edice:	Journal for ImmunoTherapy of Cancer
Témata:	Oncolytic viruses Coxsackievirus A21 Plasmacytoid DC Innate immunity Adaptive immunity
On-line přístup:	http://link.springer.com/article/10.1186/s40425-019-0632-y
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