Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of multiple parallel RTKs further enhances EGFR-TKI e...

Description complète

Détails bibliographiques

Auteurs principaux:	Patricia L Theard, Erin Sheffels, Nancy E Sealover, Amanda J Linke, David J Pratico, Robert L Kortum
Format:	Artigo
Langue:	Inglês
Publié:	eLife Sciences Publications Ltd 2020-09-01
Collection:	eLife
Sujets:	spheroids son of sevenless synergy lung adenocarcinoma
Accès en ligne:	https://elifesciences.org/articles/58204
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!