Highly efficient correction of structural mutations of 450 kb KIT locus in kidney cells of Yorkshire pig by CRISPR/Cas9

Abstract The white coat colour of Yorkshire and Landrace pig breeds is caused by the dominant white I allele of KIT, associated with 450-kb duplications and a splice mutation (G > A) at the first base in intron 17. To test whether genome editing can be employed to correct this structural mutation, a...

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Hlavní autoři:	Ke Qin, Xinyu Liang, Guanjie Sun, Xuan Shi, Min Wang, Hongbo Liu, Yaosheng Chen, Xiaohong Liu, Zuyong He
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2019-04-01
Edice:	BMC Molecular and Cell Biology
Témata:	CRISPR/Cas9 KIT Pig Structural variation
On-line přístup:	http://link.springer.com/article/10.1186/s12860-019-0184-5
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