ALKBH3-AS1 drives SMAD3 stabilization via YTHDF2: Uncovering a pathogenic pathway for Th17 dysregulation in SLE

Th17 cells and interleukin-17A (IL-17A) drive the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). Although myeloid-derived suppressor cells (MDSCs) promote the differentiation of Th17 cells, the epigenetic mechanisms remain poorly characterized. Here, we determined that...

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Autors principals:	Yanli Zhang, Yu Zhen, Zhanchuan Ma, Xiaocong Wang, Hui Yu, Cong Hu, Sensen Su, Chang Shu, Guifeng Jia, Han Qin, Yueming He, Siyuan Ma, Huanfa Yi
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-11-01
Col·lecció:	Pharmacological Research
Matèries:	Long noncoding RNA Autoimmune disease Epigenetics m6A RNA methylation Systemic lupus erythematosus
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1043661825004165
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