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Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade

Abstract Background Tumor regression following immune checkpoint blockade (ICB) is often associated with immune-related adverse events (irAEs), marked by inflammation in non-cancerous tissues. This study was undertaken to investigate the functional relationship between anti-tumor and anti-self immun...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Shuming Chen, Tracee L. McMiller, Abha Soni, Farah Succaria, John-William Sidhom, Laura C. Cappelli, Livia A. Casciola-Rosen, Isaac R. Morales, Preethi Sankaran, Alan E. Berger, Julie Stein Deutsch, Qingfeng C. Zhu, Robert A. Anders, Jody E. Hooper, Drew M. Pardoll, Evan J. Lipson, Janis M. Taube, Suzanne L. Topalian
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2024-03-01
Rangatū:Journal of Translational Medicine
Ngā marau:
COX-2
Gene expression profiling (GEP)
Immune checkpoint blockade (ICB)
Immune related adverse events (irAEs)
Melanoma
Rapid autopsy
Urunga tuihono:https://doi.org/10.1186/s12967-024-04973-7
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