Virtual screening and biological activity evaluation of novel efflux pump inhibitors targeting RE-CmeB in Campylobacter spp.

Abstract RE-CmeABC is a variant of the efflux pump CmeABC in the major zoonotic pathogen Campylobacter, which is much more potent in conferring resistance to various antibiotics for the treatment of Campylobacter infections in both veterinary and medical clinics. This potent multidrug efflux pump RE...

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Hlavní autoři:	Shihong Li, Cheng Zhang, Wenjun Li, Shuigen Wan, Jin Kang, Yong Liu, Hexiang Huang, Hao Li, Longhua Yang, Yanhong Shang, Chenglong Li, Xiangdang Du, Hong Yao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BioMed Central 2025-12-01
Edice:	One Health Advances
Témata:	Campylobacter Efflux pump variant RE-CmeABC Virtual screening Molecular simulation Activity evaluation Safety evaluation
On-line přístup:	https://doi.org/10.1186/s44280-025-00102-1
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