Recombinant sclerostin inhibits bone formation in vitro and in a mouse model of sclerosteosis
Background: Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised by excessive bone formation, is caused by absence of sclerostin, a negative regulator of bone formation that binds LRP5/6 Wnt co-receptors. Current treatment is limited to surgical management of sympt...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Elsevier
2021-07-01
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| Seri Bilgileri: | Journal of Orthopaedic Translation |
| Konular: | |
| Online Erişim: | http://www.sciencedirect.com/science/article/pii/S2214031X21000413 |
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