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Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice

The in vivo antifungal activity of the naphthoquinone beta-lapachone against disseminated infection by Cryptococcus neoformans was investigated. Swiss mice were immunosuppressed daily with dexamethasone (0.5 mg per mouse) intraperitoneally for 3 days, the procedure was repeated 4 days later, and the...

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Asıl Yazarlar: C.S. Medeiros, N.T. Pontes-Filho, C.A. Camara, J.V. Lima-Filho, P.C. Oliveira, S.A. Lemos, A.F.G. Leal, J.O.C. Brandão, R.P. Neves
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Associação Brasileira de Divulgação Científica 2010-04-01
Seri Bilgileri:Brazilian Journal of Medical and Biological Research
Konular:
Beta-lapachone
Cryptococcus neoformans
Cryptococcosis
Immunesuppression
Experimental infection
Amphotericin B
Online Erişim:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400004
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