Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment

Summary: Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs express the putative checkpoint molecule Tim-3, this protein is expressed by a much l...

Description complète

Détails bibliographiques

Auteurs principaux:	Hridesh Banerjee, Hector Nieves-Rosado, Aditi Kulkarni, Benjamin Murter, Kyle V. McGrath, Uma R. Chandran, Alexander Chang, Andrea L. Szymczak-Workman, Lazar Vujanovic, Greg M. Delgoffe, Robert L. Ferris, Lawrence P. Kane
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2021-09-01
Collection:	Cell Reports
Sujets:	regulatory T cells (Treg) T cell immunoglobulin and mucin 3 (Tim-3) cellular signaling cellular metabolism tumor immunology immunosuppression
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2211124721011463
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!