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Runt-Related Transcription Factor 3 Promotes Acute Myeloid Leukemia Progression

Acute myeloid leukemia (AML) is an aggressive hematological malignancy with high relapse/refractory rate. Genetic and epigenetic abnormalities are driving factors for leukemogenesis. RUNX1 and RUNX2 from the Runt-related transcription factor (RUNX) family played important roles in AML pathogenesis....

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Principais autores: Wenwen Zhang, Qian Ma, Bing Long, Zhangyi Sun, Lingling Liu, Dongjun Lin, Minyi Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-10-01
coleção:Frontiers in Oncology
Assuntos:
RUNX3
super-enhancer
acute myeloid leukemia
cell cycle
apoptosis
DNA repair
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2021.725336/full
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