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Network structure and fluctuation data improve inference of metabolic interaction strengths with the inverse Jacobian

Abstract Based on high-throughput metabolomics data, the recently introduced inverse differential Jacobian algorithm can infer regulatory factors and molecular causality within metabolic networks close to steady-state. However, these studies assumed perturbations acting independently on each metabol...

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Autores principales: Jiahang Li, Wolfram Weckwerth, Steffen Waldherr
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2024-11-01
Colección:npj Systems Biology and Applications
Acceso en línea:https://doi.org/10.1038/s41540-024-00457-y
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