Akebia Saponin D Targeting Ubiquitin Carboxyl‐Terminal Hydrolase 4 Promotes Peroxisome Proliferator‐Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity

ABSTRACT Promoting thermogenesis in adipose tissue to enhance energy expenditure is widely regarded as a promising strategy for obesity treatment. However, the development of effective thermogenic drugs remains challenging. Our screenings identified the natural compound Akebia Saponin D (ASD) as a p...

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Hlavní autoři:	Lang Chen, Dong‐Hai Liu, Yu‐Xi Li, Song Yang, Wei‐Hua Jia, Liang Peng, Hong‐Lin Liu, Xing‐Bo Wang, Bing Hu, Yu‐Chen Wang, Calvin Pan, Aldons Jake Lusis, Li‐Hong Liu, Li‐Li Gong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-11-01
Edice:	MedComm
Témata:	Akebia Saponin D deubiquitination mitochondria obesity ubiquitin carboxyl‐terminal hydrolase 4
On-line přístup:	https://doi.org/10.1002/mco2.70420
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