A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 enzymes Ubc4/Ubc5 and the ubiquitin ligase Tom1. tom1 cells show reduced ubiquitination of multiple RPs...

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Hlavní autoři:	Min-Kyung Sung, Tanya R Porras-Yakushi, Justin M Reitsma, Ferdinand M Huber, Michael J Sweredoski, André Hoelz, Sonja Hess, Raymond J Deshaies
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2016-08-01
Edice:	eLife
Témata:	protein quality control ribosomal protein ubiquitin-proteasome system
On-line přístup:	https://elifesciences.org/articles/19105
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