Disease-Related Protein Variants of the Highly Conserved Enzyme PAPSS2 Show Marginal Stability and Aggregation in Cells

Cellular sulfation pathways rely on the activated sulfate 3′-phosphoadenosine-5′-phosphosulfate (PAPS). In humans, PAPS is exclusively provided by the two PAPS synthases PAPSS1 and PAPSS2. Mutations found in the PAPSS2 gene result in severe disease states such as bone dysplasia, androgen excess and...

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Ngā kaituhi matua:	Oliver Brylski, Puja Shrestha, Philip J. House, Patricia Gnutt, Jonathan Wolf Mueller, Simon Ebbinghaus
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2022-04-01
Rangatū:	Frontiers in Molecular Biosciences
Ngā marau:	PAPS synthase sulfation pathways in-cell spectroscopy protein folding stability and aggregation
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.860387/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!