Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils

Abstract Accumulating evidence highlights that dysfunction of astrocyte biology might contribute to Parkinson’s disease (PD) onset and progression. Leucine-rich repeat kinase 2 (LRRK2), a gene linked to genetic and familial PD, has been reported to affect astrocytic-related functions, including the...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Alice Filippini, Giulia Carini, Alessandro Barbon, Massimo Gennarelli, Isabella Russo
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2025-05-01
Sarja:	Acta Neuropathologica Communications
Aiheet:	LRRK2 Clusterin Parkinson’s disease Astrocytes miRNA
Linkit:	https://doi.org/10.1186/s40478-025-02015-x
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