Mechanisms of Staphylococcus aureus survival of trimethoprim-sulfamethoxazole-induced thymineless death

ABSTRACT Trimethoprim-sulfamethoxazole (SXT) is commonly used to treat diverse Staphylococcus aureus infections, including those associated with cystic fibrosis (CF) pulmonary disease. Studies with Escherichia coli found that SXT impairs tetrahydrofolate production, leading to DNA damage, stress res...

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Detalhes bibliográficos

Principais autores:	Lauren J. Gonsalves, Allyson Tran, Tessa Gardiner, Tiia Freeman, Angshita Dutta, Carson J. Miller, Sharon McNamara, Adam Waalkes, Dustin R. Long, Stephen J. Salipante, Lucas R. Hoffman, Daniel J. Wolter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2024-11-01
coleção:	mBio
Assuntos:	Staphylococcus aureus thymineless death antibiotic resistance antifolate drugs persistence
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.01634-24
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