Discovery and Optimization of Ergosterol Peroxide Derivatives as Novel Glutaminase 1 Inhibitors for the Treatment of Triple-Negative Breast Cancer

In this study, novel ergosterol peroxide (EP) derivatives were synthesized and evaluated to assess their antiproliferative activity against four human cancer cell lines (A549, HepG2, MCF-7, and MDA-MB-231). Compound <b>3g</b> exhibited the most potent antiproliferative activity, with an IC<sub>50</s...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Ran Luo, Haoyi Zhao, Siqi Deng, Jiale Wu, Haijun Wang, Xiaoshan Guo, Cuicui Han, Wenkang Ren, Yinglong Han, Jianwen Zhou, Yu Lin, Ming Bu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	MDPI AG 2024-09-01
סדרה:	Molecules
נושאים:	ergosterol peroxide derivatives GLS1 inhibitors antitumor TNBC
גישה מקוונת:	https://www.mdpi.com/1420-3049/29/18/4375
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!