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Novel Tryptanthrin Derivatives with Selectivity as <i>c</i>–Jun N–Terminal Kinase (JNK) 3 Inhibitors

The <i>c</i>-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including cell proliferation and differentiation, cell survival, and inflammation. Because of emerging data suggesting that JNK3 may play an important role in neurodegenerativ...

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Principais autores: Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-06-01
coleção:Molecules
Assuntos:
anti-inflammatory
<i>c</i>-Jun N-terminal kinase
molecular docking
nuclear factor-κB
oxime
selective kinase inhibitor
Acesso em linha:https://www.mdpi.com/1420-3049/28/12/4806
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