First-in-human phase 1 dose-escalation study of W0180, an anti-VISTA monoclonal antibody, with and without pembrolizumab in patients with locally advanced or metastatic solid tumours

Objective W0180 is a humanised IgG1κ antagonistic monoclonal antibody against the V domain-containing immunoglobulin suppressor of T-cell activation (VISTA) designed to enhance antitumour activities by inhibiting the immunosuppressive role of VISTA in myeloid cells and T cells in solid tumours.Metho...

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Principais autores:	Stephane Champiat, Francois-Xavier Danlos, Aurélien Marabelle, Ignacio Melero, Carlos Gomez-Roca, Aurelie Petain, Claire Fabre, Eduardo Castañón Álvarez, Philippe Alexandre Cassier, Elena Dupuy, David Jegou, Marie Primard, Mathilde Saccareau, Geneviève Gueguen-Dorbes
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMJ Publishing Group 2026-02-01
Series:	BMJ Oncology
Acceso en liña:	https://bmjoncology.bmj.com/content/5/1/e000854.full
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