Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates

Natural killer (NK) cell functions are modulated by polymorphic killer cell immunoglobulin-like receptors (KIR). Among 13 human KIR genes, which vary by presence and copy number, KIR3DL3 is ubiquitously present in every individual across diverse populations. No ligand or function is known for KIR3DL...

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Detalhes bibliográficos

Principais autores:	Laura A. Leaton, Jonathan Shortt, Katherine M. Kichula, Sudan Tao, Neda Nemat-Gorgani, Alexander J. Mentzer, Stephen J. Oppenheimer, Zhihui Deng, Jill A. Hollenbach, Christopher R. Gignoux, Lisbeth A. Guethlein, Peter Parham, Mary Carrington, Paul J. Norman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-01-01
coleção:	Frontiers in Immunology
Assuntos:	KIR3DL3 NK cells KIR HLA class I comparative evolution infectious disease
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00024/full
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