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Rational treatment selection for primary Merkel Cell Carcinoma: a Rational MCC RCT comparing surgery and radiotherapy with parallel observational study

Background Merkel cell carcinoma is a rare locally invasive skin cancer of older people. Standard management for primary Merkel cell carcinoma is surgery and/or radiotherapy, with no standard of care or unity of practice, based on retrospective experience without randomised trials. Objectives Feasib...

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Autori principali: Neil M Steven, Sarah Pirrie, Yolande Jefferson-Hulme, Claire H Gaunt, Victoria Homer
Natura: Artigo
Lingua:Inglês
Pubblicazione: NIHR Journals Library 2025-12-01
Serie:Efficacy and Mechanism Evaluation
Soggetti:
carcinoma
merkel cell
t-lymphocytes
cytotoxic
merkel cells
merkel cell polyomavirus
cell transformation
neoplastic
biopsy
adjuvant
biomarkers
antigen-presenting cells
viral proteins
quality of life
observational study
randomised controlled trial
radiotherapy
surgery
wide local excision
Accesso online:https://doi.org/10.3310/EEWD6684
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