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PIK3CA mutation as an acquired resistance driver to EGFR-TKIs in non-small cell lung cancer: Clinical challenges and opportunities

Epithelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have significantly enhanced the treatment outcomes in non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. However, the occurrence of acquired resistance to EGFR-TKIs is an unavoidable outcome observed in the...

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Principais autores: Xiaohong Liu, Wuxuan Mei, Pengfei Zhang, Changchun Zeng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-04-01
coleção:Pharmacological Research
Assuntos:
Non-small cell lung cancer
EGFR
Resistance
PIK3CA
Combined therapy
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1043661824000677
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