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Production and cryo-electron microscopy structure of an internally tagged SARS-CoV-2 spike ecto-domain construct

The SARS-CoV-2 spike protein is synthesized in the endoplasmic reticulum of host cells, from where it undergoes export to the Golgi and the plasma membrane or retrieval from the Golgi to the endoplasmic reticulum. Elucidating the fundamental principles of this bidirectional secretion are pivotal to...

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Bibliografiske detaljer
Principais autores: Suruchi Singh, Yi Liu, Meghan Burke, Vamseedhar Rayaprolu, Stephen E. Stein, S. Saif Hasan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-06-01
Serier:Journal of Structural Biology: X
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Online adgang:http://www.sciencedirect.com/science/article/pii/S2590152425000042
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