Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA

Abstract Background Hypoxia, a typical hallmark of solid tumors, exhibits an essential role in the progression of colorectal cancer (CRC), in which the dysregulation of long non-coding RNAs (lncRNAs) is frequently observed. However, the underlying mechanisms are not clearly defined. Methods The TCGA...

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Váldodahkkit:	Li Zhou, Jingwen Jiang, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Zhe Zhang, Yan Chen, Na Xie, Wei Gao, Edouard C. Nice, Jing-Quan Li, Hai-Ning Chen, Canhua Huang
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2022-08-01
Ráidu:	Molecular Cancer
Fáttát:	Hypoxia LncRNA STEAPS-AS1 STEAP3 m6A modification YTHDF2 Wnt/β-catenin
Liŋkkat:	https://doi.org/10.1186/s12943-022-01638-1
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