A potential mutation-defined POLE/MMR/TP53 group classifications to stratify BRCA wild type epithelial ovarian cancer

Abstract Background TCGA molecular classification has prognostic value in endometrial cancer, but its application in epithelial ovarian cancer is not clear. Methods We investigated the somatic mutations of POLE, MMR (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1, PMS2) and TP53, in 181 BRCA wild type EOC patie...

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Main Authors:	Yi-Ting Chen, Po-Han Lin, Yi-Jou Tai, Heng-Cheng Hsu, Kuan-Ting Kuo, Ying-Cheng Chiang
Format:	Artigo
Language:	Inglês
Published:	BMC 2026-05-01
Series:	Journal of Ovarian Research
Subjects:	Gene mutation group classifications POLE MMR P53 Epithelial ovarian cancer
Online Access:	https://doi.org/10.1186/s13048-026-02123-9
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