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How beta-lactam antibiotics enter bacteria: a dialogue with the porins.

BACKGROUND: Multi-drug resistant (MDR) infections have become a major concern in hospitals worldwide. This study investigates membrane translocation, which is the first step required for drug action on internal bacterial targets. beta-lactams, a major antibiotic class, use porins to pass through the...

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Autori principali: Chloë E James, Kozhinjampara R Mahendran, Alexander Molitor, Jean-Michel Bolla, Andrey N Bessonov, Mathias Winterhalter, Jean-Marie Pagès
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2009-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC2677626?pdf=render
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