Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex
The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:RagB and RagC:RagD heterodimers. Rags control mTORC1 activity by tethering mTOR...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2014-11-01
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| Series: | Cell Reports |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S2211124714008730 |
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