Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling †

The antifibrotic potential of platelet-rich plasma (PRP) is controversial. This study examined the effects of PRP on in vitro transforming growth factor (TGF)-β1-induced differentiation of fibroblasts into myofibroblasts, the main drivers of fibrosis, and the involvement of vascular endothelial...

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Detalhes bibliográficos

Principais autores:	Flaminia Chellini, Alessia Tani, Larissa Vallone, Daniele Nosi, Paola Pavan, Franco Bambi, Sandra Zecchi Orlandini, Chiara Sassoli
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2018-09-01
coleção:	Cells
Assuntos:	myofibroblasts fibrosis platelet-rich plasma (PRP) vascular endothelial growth factor (VEGF)-A VEGFR-1/flt-1 Notch-1 transforming growth factor (TGF)-β1/Smad3 α-smooth muscle actin Connexin 43 confocal immunofluorescence
Acesso em linha:	http://www.mdpi.com/2073-4409/7/9/142
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