A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

Abstract Memory T cells demonstrate superior in vivo persistence and antitumor efficacy. However, methods for manufacturing less differentiated T cells are not yet well-established. Here, we show that producing chimeric antigen receptor (CAR)-T cells using berbamine (BBM), a natural compound found i...

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Bibliografische Detailangaben

Hauptverfasser:	Shin-ichiro Takayanagi, Sayaka Chuganji, Masahiro Tanaka, Bo Wang, Saki Hasegawa, Ken Fukumoto, Nariaki Wasano, Makoto Kakitani, Nakaba Ochiai, Yohei Kawai, Tatsuki Ueda, Akihiro Ishikawa, Yuko Kurimoto, Asami Fukui, Sanae Kamibayashi, Eri Imai, Atsushi Kunisato, Hajime Nozawa, Shin Kaneko
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-06-01
Schriftenreihe:	Communications Biology
Online-Zugang:	https://doi.org/10.1038/s42003-024-06297-0
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