Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells

Type I and type III interferons (IFNs) are crucial components of the first-line antiviral host response. While specific receptors for both IFN types exist, intracellular signaling shares the same Jak-STAT pathway. Due to its receptor expression, IFN-λ responsiveness is restricted mainly to epithelia...

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Detalhes bibliográficos

Principais autores:	Sudeep Bhushal, Markus Wolfsmüller, Tharini A. Selvakumar, Lucas Kemper, Dagmar Wirth, Mathias W. Hornef, Hansjörg Hauser, Mario Köster
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-06-01
coleção:	Frontiers in Immunology
Assuntos:	epithelial cell line interferon-lambda heterogeneous gene expression cell polarization small intestinal organoids
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00671/full
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