Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Abstract Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal cell functions, their interactions, and patient progno...

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Auteurs principaux:	Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2023-04-01
Collection:	Breast Cancer Research
Sujets:	Acetazolamide Acidosis Breast cancer Carbonic anhydrases ErbB2 HER2
Accès en ligne:	https://doi.org/10.1186/s13058-023-01644-1
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