Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosis

Abstract The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups. Liver injury and fibrosis were assessed using histopathology and serology. Western blotting was pe...

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Hauptverfasser: Xiaomin Hong, Sanqiang Li, Renli Luo, Mengli Yang, Junfei Wu, Shuning Chen, Siyu Zhu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-02-01
Schriftenreihe:Journal of Physiological Sciences
Schlagworte:
Alcoholic liver fibrosis
Gender differences
Estradiol
Testosterone
TGF-β1/Smad3-signaling pathway
Online Zugang:https://doi.org/10.1186/s12576-024-00901-y
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