Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity

Abstract Background Dual inhibitors of the 5-lipoxygenase-activating protein (FLAP) and the microsomal prostaglandin E2 synthase-1 (mPGES-1) may exert better anti-inflammatory efficacy and lower risks of adverse effects versus non-steroidal anti-inflammatory drugs. Despite these advantages, many dua...

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Detalhes bibliográficos

Principais autores:	Blerina Shkodra-Pula, Christian Kretzer, Paul M. Jordan, Paul Klemm, Andreas Koeberle, David Pretzel, Erden Banoglu, Stefan Lorkowski, Maria Wallert, Stephanie Höppener, Steffi Stumpf, Antje Vollrath, Stephanie Schubert, Oliver Werz, Ulrich S. Schubert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-05-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Acetalated dextran PLGA Nanoparticles Leukotriene biosynthesis FLAP inhibitor MPGES-1
Acesso em linha:	http://link.springer.com/article/10.1186/s12951-020-00620-7
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