Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research

Abstract Background Genetic engineering technology such as clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system provides a powerful tool for developing disease models and determining gene functions. Recent interests in canine cancer models have highlighted the necessity of...

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Autori principali:	Kiyoung Eun, Min Gi Park, Yeon Woo Jeong, Yeon Ik Jeong, Sang-Hwan Hyun, Woo Suk Hwang, Sung-Hak Kim, Hyunggee Kim
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2019-01-01
Serie:	BMC Biotechnology
Soggetti:	CRISPR/Cas9 Dog TP53 Knockout Cancer
Accesso online:	http://link.springer.com/article/10.1186/s12896-018-0491-5
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