Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

Abstract Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer’s disease (AD). Aβ is cleared in part by the glymphatic system, a brain-wide network of perivascular pathways that supports the exchange of cerebrospinal and brain...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Matthew Simon, Marie Xun Wang, Ozama Ismail, Molly Braun, Abigail G. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A. Haveliwala, Ryan P. O’Boyle, Warren Y. Han, Natalie Roese, Marjorie Grafe, Randall Woltjer, Detlev Boison, Jeffrey J. Iliff
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-04-01
Schriftenreihe:	Alzheimer’s Research & Therapy
Schlagworte:	Alzheimer’s disease Aquaporin-4 AQP4 α-Syntrophin glymphatic Amyloid β
Online-Zugang:	https://doi.org/10.1186/s13195-022-00999-5
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