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IL-1β and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus

Abstract Background The dentate gyrus exhibits life-long neurogenesis of granule-cell neurons, supporting hippocampal dependent learning and memory. Both temporal lobe epilepsy patients and animal models frequently have hippocampal-dependent learning and memory difficulties and show evidence of redu...

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主要な著者: Malik Zaben, Niels Haan, Feras Sharouf, Aminul Ahmed, Lars E. Sundstrom, William P. Gray
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2021-09-01
シリーズ:Journal of Neuroinflammation
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オンライン・アクセス:https://doi.org/10.1186/s12974-021-02265-1
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