Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer’s disease

Abstract Pathological tau isoforms, including hyperphosphorylated tau at serine 396 (pS396-tau) and tau oligomers (Oligo-tau), are elevated in the retinas of patients with mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) and AD dementia. These patients exhibit significant retinal gang...

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Κύριοι συγγραφείς:	Miyah R. Davis, Edward Robinson, Yosef Koronyo, Elena Salobrar-Garcia, Altan Rentsendorj, Bhakta P. Gaire, Nazanin Mirzaei, Rakez Kayed, Alfredo A. Sadun, Alexander V. Ljubimov, Lon S. Schneider, Debra Hawes, Keith L. Black, Dieu-Trang Fuchs, Maya Koronyo-Hamaoui
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2025-02-01
Σειρά:	Acta Neuropathologica Communications
Θέματα:	Alzheimer’s disease Eye Tau protein Amyloid beta Ganglion cell layer Retinal ganglion cells
Διαθέσιμο Online:	https://doi.org/10.1186/s40478-025-01935-y
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