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Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, brachydactyly B, and metastatic diseases. The domain(s) and mechanisms required for ROR2 function, however, remain unclear. W...

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Main Authors: Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2024-05-01
Series:eLife
Subjects:
WNT5A
ROR2
Frizzled
cysteine-rich domain
Kringle domain
receptor tyrosine kinase
Online Access:https://elifesciences.org/articles/71980
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