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Effects of Magnesium, Calcium, and Aluminum Chelation on Fluoroquinolone Absorption Rate and Bioavailability: A Computational Study

Fluoroquinolones (FQs) are a widespread class of broad-spectrum antibiotics prescribed as a first line of defense, and, in some cases, as the only treatment against bacterial infection. However, when administered orally, reduced absorption and bioavailability can occur due to chelation in the gastro...

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Principais autores: Daniel M. Walden, Maksim Khotimchenko, Hypatia Hou, Kaushik Chakravarty, Jyotika Varshney
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-04-01
coleção:Pharmaceutics
Assuntos:
fluoroquinolones
antibiotics
antacids
multivalent metals
pharmacokinetics
bioavailability
Acesso em linha:https://www.mdpi.com/1999-4923/13/5/594
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