Comprehensive Assessment of Indian Variations in the Druggable Kinome Landscape Highlights Distinct Insights at the Sequence, Structure and Pharmacogenomic Stratum

India confines more than 17% of the world’s population and has a diverse genetic makeup with several clinically relevant rare mutations belonging to many sub-group which are undervalued in global sequencing datasets like the 1000 Genome data (1KG) containing limited samples for Indian ethnicity. Suc...

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Principais autores:	Gayatri Panda, Neha Mishra, Disha Sharma, Rintu Kutum, Rahul C. Bhoyar, Abhinav Jain, Mohamed Imran, Vigneshwar Senthilvel, Mohit Kumar Divakar, Anushree Mishra, Parth Garg, Priyanka Banerjee, Sridhar Sivasubbu, Vinod Scaria, Arjun Ray
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2022-07-01
Serija:	Frontiers in Pharmacology
Teme:	Indian genetic variations IndiGenome Consortium pharmacogenomics single nucleotide variants docking adverse drug reactions
Online dostop:	https://www.frontiersin.org/articles/10.3389/fphar.2022.858345/full
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