CCR5 Gene Editing of Resting CD4+ T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice

CCR5 disruption by zinc finger nucleases (ZFNs) is a promising method for HIV-1 gene therapy. However, successful clinical translation of this strategy necessitates the development of a safe and effective method for delivery into relevant cells. We used non-integrating lentivirus (NILV) for transien...

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Главные авторы:	Guohua Yi, Jang Gi Choi, Preeti Bharaj, Sojan Abraham, Ying Dang, Tal Kafri, Ogechika Alozie, Manjunath N Manjunath, Premlata Shankar
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2014-01-01
Серии:	Molecular Therapy: Nucleic Acids
Предметы:	CCR5 gene editing HIV-1 therapy humanized mice non-integrating lentivirus resting CD4+ T cells zinc finger nucleases
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2162253116303353
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