Thermodynamic Correlation between Liquid–Liquid Phase Separation and Crystalline Solubility of Drug-Like Molecules

The purpose of the present study was to experimentally confirm the thermodynamic correlation between the intrinsic liquid–liquid phase separation (LLPS) concentration (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mi>S</mi><mn>0</mn><mro...

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Detalhes bibliográficos

Principais autores:	Taiga Uekusa, Tomohiro Watanabe, Daiju Watanabe, Kiyohiko Sugano
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-11-01
coleção:	Pharmaceutics
Assuntos:	liquid–liquid phase separation intrinsic solubility melting point drug-like
Acesso em linha:	https://www.mdpi.com/1999-4923/14/12/2560
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