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Role of pH in Regulating Cancer Pyrimidine Synthesis

Replication is a fundamental aspect of cancer, and replication is about reproducing all the elements and structures that form a cell. Among them are DNA, RNA, enzymes, and coenzymes. All the DNA is doubled during each S (synthesis) cell cycle phase. This means that six billion nucleic acids must be...

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Principais autores: Saad Saeed Alqahtani, Tomas Koltai, Muntaser E. Ibrahim, Adil H. H. Bashir, Sari T. S. Alhoufie, Samrein B. M. Ahmed, Daria Di Molfetta, Tiago M. A. Carvalho, Rosa Angela Cardone, Stephan Joel Reshkin, Abdelhameed Hifny, Mohamed E. Ahmed, Khalid Omer Alfarouk
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-07-01
coleção:Journal of Xenobiotics
Assuntos:
de novo nucleotide synthesis
pyrimidine
intracellular alkalosis
pH deregulation
Acesso em linha:https://www.mdpi.com/2039-4713/12/3/14
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