ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia

Abstract Background In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly understood. In this study, we investigated the roles of cold‑inducible RNA b...

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Hauptverfasser:	Tao-Yan Lin, Jun-Shuang Jia, Wei-Ren Luo, Xiao-Lin Lin, Sheng-Jun Xiao, Jie Yang, Jia-Wei Xia, Chen Zhou, Zhi-Hao Zhou, Shu-Jun Lin, Qi-Wen Li, Zhi-Zhi Yang, Ye Lei, Wen-Qing Yang, Hong-Fen Shen, Shi-Hao Huang, Sheng-Chun Wang, Lin-Bei Chen, Yu-Lin Yang, Shu-Wen Xue, Yong-Long Li, Guan-Qi Dai, Ying Zhou, Ying-Chun Li, Fang Wei, Xiao-Xiang Rong, Xiao-Jun Luo, Bing-Xia Zhao, Wen-Hua Huang, Dong Xiao, Yan Sun
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-02-01
Schriftenreihe:	Journal of Experimental & Clinical Cancer Research
Schlagworte:	Hyperthermia Nasopharyngeal carcinoma (NPC) Cold-inducible RNA-binding protein (Cirbp) Temperature-sensitive miRNA-377-3p (termed thermomiR-377-3p) Cancer stem cells (CSCs) Chemotherapy
Online-Zugang:	https://doi.org/10.1186/s13046-024-02983-3
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