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Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells

In the present study, the effect of cucurbitacin B (a natural product with anti-cancer effect) was studied on PC12 cells. It significantly reduced the cell number, changed cell morphology and inhibited colony formation while MTT results showed increased cell viability. Cucurbitacin B treatment incre...

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Principais autores: Chuanhong Wu, Jiaolin Bao, Chengwei He, Jinjian Lu, Xiuping Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Bangladesh Pharmacological Society 2015-12-01
coleção:Bangladesh Journal of Pharmacology
Assuntos:
Apoptosis
Autophagy
Cucurbitacin B
G2/M cycle
MTT
PC12 cell
Acesso em linha:https://www.banglajol.info/index.php/BJP/article/view/23791
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