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Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice

BackgroundNeuroinflammation plays fundamental, though still not fully understood, roles in the pathophysiology of substance use disorders, including cocaine addiction. Chronic cocaine exposure promotes neuroinflammatory signaling and synaptic alterations in brain regions involved in reward and memor...

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Autori principali: Gabriella Luciana de Oliveira, Maria Carolina Machado da Silva, Giovanni Freitas Gomes, Roberta dos Santos Ribeiro, Gabriela Reis Cussat, Rúbia Aparecida Fernandes, Jorge Lucas Nascimento Souza, Heliana de Barros Fernandes, Aline Silva de Miranda, Victor Rodrigues Santos, Lílian Lacerda Bueno, Luciene Bruno Vieira, Fabrício Araújo Moreira, Antônio Carlos Pinheiro de Oliveira
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-02-01
Serie:Frontiers in Pharmacology
Soggetti:
calcineurin
cocaine
FK506
neuroinflammation
plasticity
tacrolimus
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2026.1757023/full
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